TIP Companies
Discover the TIP companies driving innovation across these sectors:
Biotech / Therapeutics
Analytical Instruments / Diagnostics
Medical Devices / Consumer Health
Advanced Materials & Manufacturing
R&D Services / Consultancy
Biotech / Therapeutics
Allyx Therapeutics is a clinical stage biotechnology company based in CT. We are targeting synapse preservation as a disease-modifying approach for treating Alzheimer’s disease. Our lead candidate ALX-001 is an orally bioavailable small molecule drug which acts as a silent allosteric modulator of mGluR5 to selectively block Prion Protein initiated synaptic dysfunction. ALX-001 reversed cognitive impairment and rescued synapse loss in multiple aged transgenic mouse models of AD. The FDA has approved the IND-application for this program with first in human administration of ALX-001 in healthy volunteers currently underway.
Bactana isolates molecules expressed from commensal anaerobic bacteria to create therapies for pets that treat metabolic conditions and digestive disorders, while also developing sustainable products to reduce antibiotics and natural resource requirements during livestock production.
TIP Success Story
Bactana Signs Agreement with ArcaNatura
Bactana Signs Agreement with ArcaNatura to launch Bactana’s first commercial product, Pawsni™ Glucose Control.
CaroGen Corporation has developed transformative virus-like vesicles (VLVs) technology that can be exploited to generate safe but potent vaccines to treat various diseases.
Encapsulate is developing an automated tumor-on-a-chip system that can grow patients cancer cells outside the body, and test the efficacy of chemotherapeutic drugs against them to advocate for the best course of treatment.
EvolveImmune is building a pipeline of novel therapeutic candidates against numerous targets which are expressed on multiple immune cell types. The company's platform will generate first-in-class treatments for unmet needs in oncology and autoimmune diseases.
ImStem Biotechnology, Inc. is focusing on developing off-the-shelf cell-therapy product derived from human pluripotent stem cells(hPSC) for regeneration and autoimmune diseases treatment.
RIGImmune is a biopharmaceutical research company focused on the development of innovative RNA therapeutics to prevent or treat serious respiratory diseases with high unmet clinical needs. The company was co-founded by the prominent scientists Drs. Akiko Iwasaki and Anna Pyle from Yale University to advance the development of a novel class of oligonucleotides called stem-loop RNA therapeutics or “SLRs,” which were discovered in Dr. Pyle’s laboratory. To effectively deliver these RNA compounds without requiring lipid nanoparticle encapsulation, RIGImmune internally developed a proprietary nano-emulsion delivery technology platform named NEED™ and collaborates with SubIntro, which was co-founded by the prominent research scientists and successful respiratory drug and formulation developers, Drs. Garth Rapeport, Kazuhiro Ito, and Jag Shur. RIGImmune’s lead products aim to enhance the innate immune response against viral respiratory diseases, and treat cystic fibrosis, respectively.
Analytical Instruments / Diagnostics
Arome is bringing new approaches in analytical and computational mass spectrometry to the commercial space. We are a team of dedicated chemists, data analyst and software engineers working to gain new knowledge using our mass spectrometry platform. Our goal is to enable our clients to leverage the tools and approaches developed over many decades of innovation in drug and natural product development.
Potentiometric Probes develops and supplies voltage-sensitive dyes for academic and pharmaceutical industry researchers.
QCDx is creating novel diagnostics for personalized and early cancer detection based on a standard blood sample.
Intus Bio is using its proprietary high-resolution, high-throughput assay and analysis technology to identify bacteria and deliver answers about the microbiome, with unprecedented detail, accuracy and scale.
Medical Devices / Consumer Health
Bastion is developing an in-home device with a smartphone-based automated analyzer to measure semen quality.
Debogy is a stealth start-up with proprietary technology that can modify molecular surface structures to electrostatically destroy viral, bacterial, and fungal cells on contact.
The Feel Good Lab has developed over-the-counter pain creams for arthritis sufferers, athletes, and everyone inbetween. Getting extra relief used to require compromising your overall health with pills like ibuprofen or smelly pain creams that contain toxic fillers and preservatives.
SingleTimeMicroneedles is modernizing drug formulation and delivery with thermally-stable, multi-dose microneedle patches for drugs, vaccines, and supplements. STM's technology eliminates all cold-chain, reduces labor costs, ends biohazard waste, and improves health outcomes. With products for both humans and animals, STM is focused on helping all members in a community get and stay healthy.
Advanced Materials & Manufacturing
NANOIONIX, LLC is developing advanced ceramic materials with breakthrough performance, solving some of the world’s most challenging problems in healthcare and energy technology.
PiezoBioMembrane is pioneering a novel category of biodegradable piezoelectric materials tailored for implantable applications.
R&D Services / Consultancy
Enable Life Sciences facilitates Innovation in the life sciences. We bring the innovative plans and aspirations of our clients to reality through Planning, Creation and Execution. We enable success through customized Innovation Management and R&D Project Management services, including collaborations at a global scale.
